RNA Details
Disease Name
atrial fibrillation
Tissue
heart
RNA Symbol
miR-450a-2-3p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
RT-qRT-PCR;GO
Target
MAPK1
Pathway
NA
PubMed ID
Title
Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation
Year
2021
Function
"The overexpression of miR-450a-2-3p suppressed the MAPK1 expression in cardiac fibroblasts (CFs), thereby inhibiting the expression of alpha-SMA, COL1, and COL3 and preventing CF proliferation."